The expression and significance of Survivin and p73 in human colorectal carcinoma

Objective:To investigate the expression and significance of Survivin and p73 in human colorectal carcinoma.Methods:S-P immunohistochemical techniques and image analysis were used to detect the expression of Survivin and p73 in tumor tissue,para-tumor tissue and normal mucos of human colorectal caucinoma.Results:In 60 patients,the average values of light density of Survivin in tumor para-tumor and normal tissus were 0.5443±0.0385,0.3263±0.0284,0.1467±0.0227 and p73 were 0.7617±0.0251,0.5327±0.0318,0.3460±0.0223 respectively.A high expression of Survivin and p73 was discovered in tumor tissue(P0.01) in tumor tissue,para-tumor tissue and normal mucosa of human colorectal carcinoma.The expression of Survivin and p73 had a linear correlation and the correlation coefficient was 0.783.There was a positive correlation between the expression of Survivin and p73 in human colorectal carcinoma.Conclusion:Survivin and p73 might play an important role in the development of human colorectal carcinoma,and Survivin and p73 had a coordinated effect in the course of development of human colorectal carcinoma.