Comparison of clinical therapeutic effect of sequential therapy and standard triple therapy for Helicobacter pylori

Objective To study the clinical effects of sequential therapy and standard triple therapy for Helicobacter pylori.Methods 120 cases with positive Helicobacter pylori were divided into A group and B group according to the number table method,60 cases in each group.A group received sequential therapy （ omeprazole＋amoxicillin treatment after 5 days continue to omeprazole clarithromycin and metronidazole treatment for 5 days）,B group received standard triple therapy （ omeprazole ＋amoxicillin ＋clarithromycin ） , eradication rate of Helicobacter pylori,the total efficiency of ulcer healing and adverse reaction of the two groups were compared.Results The eradication rate of Helicobacter pylori of group A was 91.7%（55/60）,which was significantly higher than 71.7%（43/60） of group B （χ^2 =11.915,P=0.023）;the ulcer healing and the total effective rate of group A was 96.7%（58/60）,which was significantly higher than 88.3%（53/60） of group B,the difference was statistically significant （χ^2 =9.915,P=0.038）;there was no statistically significant difference between the two groups in adverse reaction （χ^2 =4.735,P=0.072）.Conclusion Sequential therapy has a better effect in treatment Helicobacter pylori than the standard triple therapy, which can significantly improve the eradication of Helicobacter pylori, with no serious adverse reactions. Key words: Sequential therapy; Drug therapy,combination; Helicobacter pylori