Comparison between clinical effects of two kinds of triple therapy for the eradication of helicobacter pylori infection in gastric ulcer

Objective To compare and discuss the clinical effects of two kinds of triple therapy for the eradication of helicobacter pylori infection(HP) in gastric ulcer. Methods A total of 46 cases of helicobacter pylori-associated gastric ulcer patients were divided into control group and observation group, and each group contained 23 cases. Omeprazole, amoxicillin and metronidazole were used in the control group for treatment, while omeprazole, amoxicillin and clarithromycin were applied in the observation group. Comparison was made between the clinical effects and helicobacter pylori bacterial eradication rates of patients treated by different triple therapy. Results After 4 weeks of treatment, there were 4 cured cases, 12 effective cases and 7 ineffective cases in the control group, and the total effective rate was 69.56%. In the observation group, there were 9 cured cases, 13 effective cases and 1 ineffective case, and the total effective rate was 95.65 %. The difference between the two groups was statistically significant(P0.05). The HP eradication rate of the control group was 60.87%(14/23), and that of the observation group was 86.97%(20/23). The difference had statistical significance(P0.05). Conclusion In treating the helicobacter pylori-associated gastric ulcer, the triple therapy using omeprazole, amoxicillin, and clarithromycin has better clinical effect than the application of omeprazole, amoxicillin, and metronidazole. The former can improve HP eradication rate and promote healing of ulcers, which is worthy of clinical reference and promotion.