COMPARISON OF THE EFFICACY OF TEN-DAY SEQUENTIAL THERAPY AND CONVENTIONAL TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION

[Objective]To compare the efficacy of ten-day sequential therapy and conventional triple therapy for Helicobacter pylori eradication.[Methods]89 patients with proven Helicobacter pylori infection received ten-day sequential therapy(40 mg of Omeprazole,and 1g of amoxicillin for the first 5 days,followed by 40 mg of Omeprazole,40 mg of Levofloxacin and 500 mg of clarithromycin).In controls,44 patients received conventional triple therapy(40 mg of Omeprazole,500mg Clarithromycin and 1g amoxicillin).[Results]Eradication was evaluated 4?weeks and 6 months later,after completion of treatment.The eradication rate of sequential therapy was 93.0% and 79.6% in experimental group and control group,the difference was significant.The healing rate of ulcer was 81.4% and 61.2%in experimental group and control group,the difference was significant.The ulcer recurrence rate was l2.5% and 33.3% in experimental group and control group,there was significant difference.[Conclusion]Sequential therapy is more effective for eradicating Helicobacter pylori infection than conventional triple therapy.