Sedative effect and safety of small doses of Sufentanil combined with Propofol in painless gastroscopy

Objective To investigate the Sedative effect and safety of intravenous Sufentanil combined with Propofol in painless gastroscopy. Methods 270 patients with ASA I-II were randomly divided into three groups: Group A (the Propofol group), Group B (the Fentanyl combined with Propofol group) and Group C (the Sufentanil combined with Propofol group). HR, MAP and SpO2 were monitored at three different time points: before placement of the gastroscope, during and 5 minutes after gastroscopy. The time required for consciousness recovery, the time required for regaining orientation, the operating time for gastroscopy and the dosage of Propofol were recorded. Results HR, MAP and SpO2 were obviously lower during operation than before or after operation in each group (P<0.05) and were significant different among the groups (P<0.05). The times required for consciousness recovery and for regaining orientation, respectively, were significantly longer in Group A than in Group B or C, and there was a significantly difference between Group B and Group C (P<0.05). The total dose of Propofol in Group A was significantly larger than that in Group B or C (P<0.05). Conclusions Compared with Propofol alone or Fentanyl combined with Propofol, Sufentanil can be used in combination with lower does of Propofol in painless gastroscopy to produce rapid and effective Sedation, with fewer side effects and higher patient satisfaction. Key words: Sufentanil; Propofol; Gastroscopy