Evaluation of the Effect and Security on Remifentanil-Propofol and Fentanyl-Propofol in Gastroscopy

Objective: To evaluate the sedative and analgesic efficiency and security of remifentanil-propofol and fentanyl-propofol by intravenous injection in gastroscopy. Methods: 331 patients were randomly divided into three groups: remifentanil-propofol (group Ⅰ), fentanyl-propofol (group Ⅱ) and ordinary gastroscopy group (group Ⅲ, as control). The variation of BP, HR, SPO2, and the reaction of patients during examination were observed. The serum norepinephrine concentrations were measured before and after gastroscopy. Questionnaires for patients were performed after gastroscopy. Results: All operations were completed easily without significant complication. Much less discomfort of patients were observed in groupⅠand Ⅱthan in groupⅢ (P0.01).The time of operation in groupⅠandⅡwere shorter than in groupⅢ (P0.01). The awaken time in groupⅠwas shorter than in group Ⅱ (P0.01).The BP and SPO2 decreased during the procedure in groupⅠand Ⅱ, however, they recovered to baseline immediately after gastroscopy. HR and BP during the procedure increased significantly in group Ⅲ than in groupⅠand Ⅱ (P0.01). All serum NE concentrations were increased after gastroscopy (P0.01), and significantly higher in group Ⅲ than in groupⅠandⅡ(P0.01). Conclusion: Using remifentanil-propofol and fentanyl-propofol via intravenous injection can reduce stress in gastroscopy and make gastroscopy more comfortable, more effective and safer, especially remifentanil-propofol is more suitable for gastroscopy with sedation.