Clinical efficacy of esomeprazole auxiliary treatment of 16 cases of reflux esophagitis

Objective To evaluate the efficacy of esomeprazole combined with mosapride in the treatment of reflux esophagitis.Methods From February 2010 to March 2013,32 patients with reflux esophagitis were randomly divided into two groups,16 cases in each group.Observation group received esomeprazole and mosapride,while control group received omeprazole and mosapride.The efficacy of two groups was observed and compared.Results The total effective rate in observation group was 93.75％,that in control group was 81.25％,with statistical significant difference (P ＜ 0.05).There was no statistical significant difference in major symptom score between two groups before treatment; after treatment,symptom scores of acid reflux,heartburn,swallowing difficulty and retrostemal pain improved significantly (P ＜ 0.05).The incidence of adverse reactions in observation group was 6.25％,that in control group was 18.75％,with statistical significant difference (P ＜ 0.05).Conclusion Esomeprazole combined with mosapride in the treatment of reflux esophagitis is effective,worthy of clinical promotion. Key words: Esomeprazole;  Mosapride;  Omeprazole;  Efficacy