Effect of tiotropium combined with salmeterol/fluticasone for the treatment of chronic obstructive pulmonary disease

Objective To study the efficacy and safety of tiotropium and salmeterol/fluticasone on chronic obstructive pulmonary disease (COPD).Methods Fifty patients with stable moderate -severe COPD were randomly divided into 3 groups:18 cases in combined group (group Ⅰ,tiotropium +salmeterol/fluticasone),15 cases in tiotropium group (group Ⅱ ),while 17 cases in salmeterol/fluticasone group ( group Ⅲ ).Three groups were given conventional oxygen,antibiotics and other symptomatic treatment,the follow - up period was 3 months.Arterial blood gas analysis,pulmonary function and 6 - minute walk distance (6MWD) were measured before and 3 months after treatment.Results PaO2,FEV1 and 6MWD were improved in all groups compared with that before treatment( P ＜ 0.05),especially in combination group ( P ＜ 0.05 ).Conclusions Tiotropium combined with salmeterol/fluticasone in the treatment of moderate - severe COPD with arterial blood gas analysis,pulmonary function and exercise tolerance is more effective than only tiotropium or salmeterol/fluticasone inhalation.It is safe and worthy of being extended in clinics. Key words: Chronic obstructive pulmonary disease; Tiotropium; Salmeterol/fluticasone; Blood gas analysis; Lung function