Therapy Efficacy of Tiotropium Combined Salmeterol/Fluticasone in Patients with Chronic Obstructive Pulmonary Disease

Objective To explore the therapy efficacy of tiotropium plus salmeterol/fluticasone in patients with chronic obstructive pulmonary disease(COPD).Methods 100 patients with severe-to-very severe COPD were randomly divided into two groups:combination treatment group(tiotropium combined salmeterol/fluticasone),control group(tiotropium),50 patients in each group.The pulmonary function,degree of dyspnea,6 minute walk distance,body mass index,and the scores of quality of life before the treatment and 6 months after the treatment were compared between the two groups.Results By the end of 6 months treatment,the pulmonary function(FEV1,FEV1%),6 minute walk distance,the scores of quality of life and the scores of degree of dyspnea were significantly improved in both groups(P0.05),and the improvement in combination group was more significant(P0.05).The body mass index was improved in both groups,but the difference was not significant(P0.05),the difference between the two groups was not significant(P0.05).Conclusion The joint usage of tiotropium and salmeterol/fluticasone in patients of severe COPD is better than salmeterol/fluticasone in improving pulmonary function,exercise tolerance,symptoms,and quality of life.