Salmeterol/Fluticasone Combined with Tiotropium in Treatment of Stable Moderate and Severe COPD Patients

Objective:To observe the therapeutic effects of salmeterol/fluticasone combined with tiotropium in the treatment of stable moderate and severe COPD.Methods:Sixty patients of stable moderate and severe COPD were randomly divided into three groups: salmeterol/fluticasone group、tiotropium group and combination group.The salmeterol/fluticasone group received the therapy of salmeterol/fluticasone only,the tiotropium group received the therapy of tiotropium only and the combination group received the therapy of tiotropium and salmeterol/fluticasone.All patients had received the treatment for 6 months.Lung function and arterial blood gas analysis results before and after treatment and adverse effects of three groups were recorded.Results:After therapy,lung function and arterial blood gas analysis results of all patients were improved.Compared with the salmeterol/fluticasone group and tiotropium group,arterial blood gas analysis results、FEV1/FVC and FEV1 of the combination group improved significantly(P0.05).No serious adverse effects occurred during the treatment.Conclusions:The combination therapy with salmeterol/fluticasone and tiotropium of stable moderate and severe COPD patients has remarkable curative effect without serious adverse effects.