Clinical and imaging features of 45 patients with sarcoidosis

Objective To explore the clinical and imaging features, improve the clinical diagnostic accuracy of sarcoidosis. Methods Clinical data of 45 patients with biopsy-proven sarcoidosis were retrospectively analyzed. Results Sarcoidosis had several clinical features including pulmonary and extropulmonary presentation.The mainly symptoms of respiratory system were cough, expectoration, followed by chest tightness, which accounted for 55.6%, 48.9% and 44.4% respectively.Systemic symptoms were nonspecific.The peripheral lymph node enlargement and subcutaneous nodules were common, which accounted for 31.1% and 24.4%.Laboratory examination showed higher erythrocyte sedimentation rate and normal C-reactive protein.CD4/CD8 in bronchoalveolar lavage fluid of 84.2% patients was increased (more than 3.5). The symmetrical lymph node enlargement was common in pulmonary CT scan (55.6%). The diagnosis was depended on histopathology. Conclusions It is important to be aware of sarcoidosis features including pulmonary and extropulmonary presentation.Auxiliary examination is helpful for diagnosis, as far as possible to perform biopsy to confirm the diagnosis.Oral glucocorticoid is the effective drug for therapy. Key words: Sarcoidosis; Imaging; Clinical feature