Clinical observation of interferon by aerosol inhalation as a part of treatment of hand-foot-and-mouth disease of children

Objective To observe the clinical efficacy of interferon by aerosol inhalation as a part of treatment of hand, foot and mouth disease of children. Methods The clinical data of 240 children with hand foot and mouth disease were collected, and they were divided into group A (control group) and group B (interferon treatment group) according to the order of admission.The recovery time on body temperature, rashes on the hands and feet, mouth pain, the average hospitalization time and total efficacy rate were compared. Results Group B was superior to group A in the following aspects, it took shorter time to get recovery of mouth pain, rashes on hands and feet, the average hospitalization time.The recovery time for mouth pain of group A was (60.5±22.1)h, which of group B was (52.8±19.5)h.The time for rashes on hand and foot recovery of group A was (72.3±25.4)h, which of group B was (54.7±22.5)h.The average hospitalization time of group A was (124.8±42.4)h, which of group was B (108.2±36.7)h, and the differences were statistically significant (t=2.45, 2.38, 2.16, P=0.018, 0.015, 0.032). The total effective rate of group B was 93%, which was higher than 85.3% of group A, and the difference was statistically significant (χ2=6.012, P=0.012). Conclusion Interferon by aerosol inhalation as a part treatment of hand-foot-and-mouth disease of children (ordinary type) can increase the efficacy rate, shorten course of the disease, accelerate comprehensive rehabilitation of patients. Key words: Hand-foot-and-mouth disease; Interferon