2014•Xiandai yaowu yu linchuangRequires access
Clinical observation of Recombinant Human Interferon α-2b Injection by aerosol inhalation in treatment of hand-foot-mouth disease of children
Zhang Xiao-da
Open publisher page 1 citations
Abstract
Objective To observe the clinical efficacy of Recombinant Human Interferon α-2b Injection by aerosol inhalation in treatment of hand-foot-mouth disease of children. Methods The children(164 cases) diagnosed with hand-foot-mouth disease in Beijing YouAn Hospital, Capital Medical University from May to September 2013 were randomly divided into treatment(84 cases) and control(80 cases) groups. The children in the control group were administered with symptomatic treatment. On the basis of the control group, the children in the treatment group were administered with Recombinant Human Interferon α-2b Injection 3 million U, twice daily by compressed air and aerosol inhalation, which was diluted by physiological saline 2 mL. The flow rate was 4 L/min. Both the children in the two groups were observed for 7 d. A treatment period was 3 d. The improvement of the body temperature, feeding, and herpes of children in the two groups was obtained in 3 and 6 d during the treatment. Results The effect in the treatment group was better than that in the control group. The total efficacies in the treatment and control groups were 98.8% and 91.3%, respectively, with the significant difference between the two groups(P 0.05). The effect of body temperature and herpes of the children in the treatment group in 3 and 6 d during the treatment was better than that of the children in the control group, with the significant difference between the two groups(P 0.05). The difference of feeding in the two groups in 3 and 6 d was not statistically significant. Conclusion Recombinant Human Interferon α-2b Injection by aerosol inhalation in the treatment of hand-foot-mouth disease of children can promote the temperature recovery and herpes healing of the children with hand-foot-mouth disease, and the therapeutic effect is reliable and safety in clinic is satisfied. So it is worth further researching and widely using in clinic.