2006肿瘤研究与临床Requires access

Level of serum vascular endothelial growth factor in patients with breast cancer

梁启廉, 陈小东, 李建文, 王三明, 张远起, 李小英, 杨勤, 谢杰荣

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Abstract

目的 测定乳腺癌患者血清血管内皮生长因子(vascular endothelial growthfactor,VEGF)水平,探讨手术对乳腺癌患者血清VEGF水平的影响.方法采用酶联免疫吸附试验法(ELISA)检测32例正常人和58例乳腺癌患者手术前血清VEGF水平,并比较40例乳腺癌患者手术前后血清VEGF水平.结果血清VEGF浓度与乳腺癌患者临床分期有关,与乳腺癌患者年龄、病理类型无相关;乳腺癌患者血清VEGF水平明显高于正常对照组(P<0.01);Ⅳ期乳腺癌血清VEGF水平明显高于其他各期(P<0.01),Ⅲ期明显高于Ⅱ期(P<0.01),Ⅱ期明显高于Ⅰ期(P<0.01);乳腺癌患者术后血清VEGF水平明显低于术前(P<0.01).结论血清VEGF可能与乳腺癌的发生发展有一定相关关系,血清VEGF检测对乳腺癌患者病情判断、疗效和预后评价有一定的临床意义。

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What this paper is about

目的 测定乳腺癌患者血清血管内皮生长因子(vascular endothelial growthfactor,VEGF)水平,探讨手术对乳腺癌患者血清VEGF水平的影响.方法采用酶联免疫吸附试验法(ELISA)检测32例正常人和58例乳腺癌患者手术前血清VEGF水平,并比较40例乳腺癌患者手术前后血清VEGF水平.结果血清VEGF浓度与乳腺癌患者临床分期有关,与乳腺癌患者年龄、病理类型无相关;乳腺癌患者血清VEGF水平明显高于正常对照组(P<0.01);Ⅳ期乳腺癌血清VEGF水平明显高于其他各期(P<0.01),Ⅲ期明显高于Ⅱ期(P<0.01),Ⅱ期明显高于Ⅰ期(P<0.01);乳腺癌患者术后血清VEGF水平明显低于术前(P<0.01).结论血清VEGF可能与乳腺癌的发生发展有一定相关关系,血清VEGF检测对乳腺癌患者病情判断、疗效和预后评价有一定的临床意义。

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Available abstract

目的 测定乳腺癌患者血清血管内皮生长因子(vascular endothelial growthfactor,VEGF)水平,探讨手术对乳腺癌患者血清VEGF水平的影响.方法采用酶联免疫吸附试验法(ELISA)检测32例正常人和58例乳腺癌患者手术前血清VEGF水平,并比较40例乳腺癌患者手术前后血清VEGF水平.结果血清VEGF浓度与乳腺癌患者临床分期有关,与乳腺癌患者年龄、病理类型无相关;乳腺癌患者血清VEGF水平明显高于正常对照组(P<0.01);Ⅳ期乳腺癌血清VEGF水平明显高于其他各期(P<0.01),Ⅲ期明显高于Ⅱ期(P<0.01),Ⅱ期明显高于Ⅰ期(P<0.01);乳腺癌患者术后血清VEGF水平明显低于术前(P<0.01).结论血清VEGF可能与乳腺癌的发生发展有一定相关关系,血清VEGF检测对乳腺癌患者病情判断、疗效和预后评价有一定的临床意义。

Key concepts: Breast cancer, Medicine, Cancer, Vascular endothelial growth factor, Internal medicine, Oncology, VEGF receptors

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