2003肿瘤研究与临床Requires access

CLINICAL SIGNIFICANCE OF SERUM VEGF LEVEL IN PATIENTS WITH BREAST CANCER

陈晓群, 伍治平, 蒋永新, 金从国, 陈艳, 谷玉兰

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Abstract

目的:探讨血清血管内皮生长因子(vascular endothelial growth factor,VEGF)在乳腺癌诊断、预后及疗效观察中的意义.方法:用双抗夹心ELISA方法测定40例乳腺癌患者血清的VEGF水平,另用40名健康人的血清VEGF水平作对照.用SPSS10.0统计软件包进行统计分析.结果:乳腺癌患者血清VEGF水平显著高于健康人(P=0.000);晚期乳腺癌(Ⅲ期、Ⅳ期)患者血清VEGF水平高于早期乳腺癌(Ⅰ期、Ⅱ期)患者,差异有显著性(P=0.002);有淋巴结转移者高于无淋巴结持移者(P=0.003).结论:血清VEGF可能成为乳腺癌的一个新的肿瘤标志物,用于乳腺癌的诊断和动态监测病情进展、预后判断.

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目的:探讨血清血管内皮生长因子(vascular endothelial growth factor,VEGF)在乳腺癌诊断、预后及疗效观察中的意义.方法:用双抗夹心ELISA方法测定40例乳腺癌患者血清的VEGF水平,另用40名健康人的血清VEGF水平作对照.用SPSS10.0统计软件包进行统计分析.结果:乳腺癌患者血清VEGF水平显著高于健康人(P=0.000);晚期乳腺癌(Ⅲ期、Ⅳ期)患者血清VEGF水平高于早期乳腺癌(Ⅰ期、Ⅱ期)患者,差异有显著性(P=0.002);有淋巴结转移者高于无淋巴结持移者(P=0.003).结论:血清VEGF可能成为乳腺癌的一个新的肿瘤标志物,用于乳腺癌的诊断和动态监测病情进展、预后判断.

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Available abstract

目的:探讨血清血管内皮生长因子(vascular endothelial growth factor,VEGF)在乳腺癌诊断、预后及疗效观察中的意义.方法:用双抗夹心ELISA方法测定40例乳腺癌患者血清的VEGF水平,另用40名健康人的血清VEGF水平作对照.用SPSS10.0统计软件包进行统计分析.结果:乳腺癌患者血清VEGF水平显著高于健康人(P=0.000);晚期乳腺癌(Ⅲ期、Ⅳ期)患者血清VEGF水平高于早期乳腺癌(Ⅰ期、Ⅱ期)患者,差异有显著性(P=0.002);有淋巴结转移者高于无淋巴结持移者(P=0.003).结论:血清VEGF可能成为乳腺癌的一个新的肿瘤标志物,用于乳腺癌的诊断和动态监测病情进展、预后判断.

Key concepts: Breast cancer, Medicine, VEGF receptors, Clinical significance, Oncology, Internal medicine, Cancer

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