Effect of early blood pressure-lowering treatment on the growth of hematoma in patients with hypertensive intracerebral hemorrhage

Objective To investigate the effect of early blood pressure-lowering treatment on the growth of hematoma in patients with hypertensive intracerebral hemorrhage.Methods One hundred and seventeen patients with hypertensive cerebral hemorrhage within 3 hours of onset were chose,the basic data were collected,the blood pressure was dynamicly monitored,the management of blood pressure after admission and intervention time was recorded,antihypertensive medications of urapidil was intravenously given to control blood pressure,according to the systolic blood pressure,they were divided into three groups,Group A:140 mm Hg≤SBP ＜ 159 mm Hg; Group B:160 mm Hg≤SBP ＜ 179 mm Hg; Group C:180 mm Hg≤SBP ＜ 199 mm Hg.According to the chef formula,the hematoma volume was calculated,hematoma volume on admission and hematoma volume at 24 hours after stroke onset was compared,the hematoma volume increased by 33％ was judged by hematoma enlargement,the obtained data were statistically analyzed.Results Patients with hypertensive intracerebral hemorrhage in acute stage treated with intravenous antihypertensive drugs to control the systolic blood pressure in different levels,the incidences of hematoma enlargement also were obviously different,which the hematoma enlargement the rate of group A was the lowest (13.16％) ; the hematoma enlargement rates of group B and group C were 33.33％ and 56.76％,showed that the higher was systolic blood pressure,the easier hematoma was enlarged,and when blood pressure was controled in the lower levels of 140-159 mm Hg,patients had the lowest risk of hematoma expansion.Conclusions Early intensive treatment for the acute phase of hypertensive cerebral hemorrhage is clinically feasible and has good tolerance,can reduce the enlargement of hematoma and improve the prognosis. Key words: Intracerebral hemorrhage ;  Hypertension ;  Blood pressure-lowering;  Hematoma enlargement