Influence of early intensively antihypertensive therapy on hematoma enlargement in patients with hypertensive intracerebral hemorrhage

Objective To investigate the influence of early intensively antihypertensive therapy on hematoma enlargement in patients with hypertensive intracerebral hemorrhage(HICH).Methods 256 acute HICH patients with blood pressure 180/110 mmHg were randomly divided into two groups.A group(128 cases)was given intensively antihypertensive therapy,B group(128 cases)was given standard guideline antihypertensive therapy.The efficacy was evaluated by hematoma volume 24 h after treatment and the National Institutes of Health Stroke Scale(NIHSS)before and 21 d after treatment.Results The mean hematoma volume before and 24 h after treatment in A group were(20.5±2.76)ml and(23.3±2.32)ml,and 11 cases(8.59%)had hematoma enlargement;while the mean hematoma volume in B group were(20.2±2.87)ml and(26.5±2.48)ml,and 29 cases(22.66%)had hematoma enlargement.There was statistical difference between the two groups(all P0.01).The scores of NIHSS before and 21 d after treatment in A group were(26.5±7.42)and(16.5±9.26),while in B group were(25.8±7.93)and(19.7±10.40).There was also statistical difference between the two groups at 21 d after treatment(P0.05).Conclusion Early intensively antihypertensive therapy is helpful to control hematoma enlargement in HICH patients.