Effect and Safety of Early Intensive Blood Pressure Reduction in Patients with Acute Cerebral Hemorrhage

Objective To evaluate the efficacy and safety of intensive blood pressure(BP) reduction in patients with acute cerebral hemorrhage.Methods A total of 106 patients with acute cerebral hemorrhage were randomly divided into blood pressure reduction group and traditional group.Patients in traditional group were treated traditional guideline-based management of BP,and Patients in blood pressure reduction group were treated to early intensive lowering of BP(140/90mm Hg).After 24 hours,7 days,Comparison of two groups were made in enlargement of hematoma volume,and compared with clinical outcomes(mortality,neurological functional deficit scales,complications) after 3 months.Results After 24 hours,there were no significant difference(P0.05) in average hematoma volume between two groups,and the enlarged volume and percentage of hematoma were 2.30ml,7.76ml and 15.73%,39.06%,the difference were significant(P0.01).There were no significant difference(P0.05) in average volume,enlarged volume and percentage of hematoma after 7 days.And after 3 months,There were also no significant difference(P0.05) in clinical outcomes.Conclusion Early intensive BP-lowering treatment can reduce haematoma growth in acute cerebral hemorrhage,and safe.