Effect of valsartan on angiogenesis and miR29 expression in rats with acute myocardial infarction

Objective To observe the effect of valsartan on angiogenesis and miR29 expression after myocardial infarction. Methods Sixty male Wistar rats were randomly divided into model group, sham operation group and valsartan group. Left anterior descending artery was Ligated to establish myocardial infarction model.After operation, valsartan group received valsartan 30 mg/(kg·d) by gavage for 4 weeks, the model group and sham operation group were given equivalent solvent orally. After 4 weeks, the animals were sacrificed and the expression of miR29 was detected by immunohis to chemical staining of myocardium in the infarct area. Results In the valsartan group, micro vessel count compared with the model group increased, model group compared with the sham operation group increased, the differences were significant (P<0.05). The expression of miR29 levels in valsartan group decreased (P<0.01), there were significant differences between model group and sham operation group(P<0.01). Conclusions Valsartan can inhibit ventricular remodeling in rats after acute myocardial infarction. It can promote myocardial angiogenesis in rats with acute myocardial infarction and reduce the expression of miR29. Key words: Myocardial infarction; Myocardial remodeling; Angiogenesis; miR29