Effects of rosuvastatin on angiogenesis and expression of miR-126 after acute myocardial infarction in rats

Aim: To investigate whether rosuvastatin could up-regulate the expression of miR-126 after acute myocardial infarction in rats and study its relationship with angiogenesis. Methods: A total of 54 rats were established acute myocardial infarction model and randomly allocated into the model group and the rosuvastatin group with 27 in each group. Then the rats in the rosuvastatin group were given rosuvastatin at 10 mg /( kg·d) by gavage for 6 weeks,and those in the model group were given equivalent solvent. After 6 weeks,the rats were executed and the myocardial infarction samples were prepared. The myocardial microvessel density was detected by immunohistochemical staining,and the expression level of miR126 was determined by real time PCR. Results: Compared with the model group,the microvessel density and the expression level of miR-126 in rosuvastatin group obviously elevated( t = 2. 386 and 3. 264,P 0. 05); the 2 parameters were positively related in myocardial infarction tissue of rosuvastatin group( r = 0. 720,P = 0. 026). Conclusion: Rosuvastatin may promote angiogenesis in rat infarction myocardium by upregulating the expression of miR-126.