The changes of plasma miR-214 expression in rats with post acute myocardial infarction in Rat

Objective To detect the change of expression level of plasma miR-214 in rats with post acute myocardium infarction.Methods Rats underwent left descending coronary ligation or sham surgery.Rats with MI was assigned to two groups(n=5).Real-time PCR was developed to detect the expression of miR-214 in plasma.Results The expression level of miR-214 in plasma was up-regulated in the 14th and 28th day post MI.Compared to sham group,the expression level of miR-214 increased by 60%(1.60±0.09 vs 1.00±0.06,P0.01) in the 14th day and by 116%(2.16±0.13 vs 1.00±0.06,P0.01) in the 28th day post MI.Conclusion The expression of plasma miR-214 increases with ventricular remodeling post MI in rat.MiR-214 may be involved in ventricular remodeling post MI.