Study on pharmacologic actions of traditional Chinese formula on pressure ulcer

Objective To discuss the anti-inflammatory and analgesic effects of traditional Chinese formula (TCF)on pressure ulcer. Methods The experimental animals were randomly divided into TCF high-dose group, TCF low dose group, indomethacin group, and saline group. through the inhibition of rat carrageenin paw edema test, acetic acid-induced small murine peritoneal capillary permeability experiments, acetic acid-induced writhing response in mice experiments,subjects observe the animals indicators. Results Rat plantar subcutaneous injection of carrageenan-induced inflammation,the compound traditional Chinese medicine set of square high-dose group 1 ～6 h paw edema was significantly lower than saline control group (P＜0.05), 2～6 h anti-inflammation and indomethacin Xin was no significant difference (P＞0.05);compound Chinese medicine set of square high-dose group and low dose group mice dye leakage reduction compared with the saline group was statistically significant (P＜0.05), high-dose group and the indomethacin group effect was no significant difference in strength (P＞0.05); compound Chinese medicine set of square high-dose group and low dose group the number of writhing response in mice compared with saline significantly reduce(P＜0.05). Conclusion Prescription medicine compound high-dose, low dose has anti-inflammatory effects, analgesic effects, Pharmacological effect was dose-proportional relationship. Key words: Pressure ulcer ;  Medicines party ;  pharmacological effects ;  Inflammatory effects ;