Clinical investigation on relationship among lipoprotein(a), cerebral infarction and carotid atherosclerosis

Objective To investigate the correlation among Lp(a), cerebral and carotid atherosclerosis. Methods 180 cases were equally divided into 3 groups(60 cases in each group). The patients with both cerebral and carotid atherosclerosis composed one group(cerebral for short); the patients of carotid atherosclerosis which without cerebral composed another group(no cerebral infarction group for short); the control group composed with those who had neither cerebral nor carotid atherosclerosis. The level, outlier detection rate about Lp(a)and usual risk factors of cerebral were compared in this research. Results The level and detection rate of Lp(a)in the cerebral group were(512±156)mg/L and 46.7%;the level and detection rate of Lp(a)in the no cerebral group were(316±87)mg/L and 20.0%; the level and detection rate of Lp(a)in the control group were(199±123)mg/L and 5.0%. The differences of the level and outlier detection rate of Lp(a)among the three group were significant(F= 13.87,χ2= 29.394,P< 0.01). Cerebral patients had more usual risk factors of cerebral (hypertension, diabetes, hyperlipemia, drinking, smoking, obesity and lack of exercise)than those who without cerebral infarction(χ2= 15.523,P< 0.01). Conclusion The abnormal of Lp(a) was an important risk factor of cerebral infarction. The general survey of Lp(a) was significant in the primary and secondary prevention of stroke. To the people whose assay of Lp(a)was abnormal, the control of governable risk factors of cerebral should actively be carried out. Key words: Lipoprotein(a); Cerebral infarction; Carotid artery diseases; Atherosclerosis