The change of serum homocysteine level in patients with primary hypertension and acute cerebral infarction

Objective To study the relationship between serum homocysteine level and primary hypertension and acute cerebral infarction patients. Methods 96 acute cerebral infarction patients were selected,including 42 cases with pure cerebral infarction( cerebral infarction group) and 54 cases of primary hypertension and cerebral infarction patients( hypertension and cerebral infarction group) ;48 cases of pure primary hypertension were selected as hypertension group;40 healthy persons were selected as control group. To observe the serum Hcy level of all subjects and the cerebral infarction situation of cerebral infarction group, hypertension and cerebral infarction group. Results The serum Hcy level of moderate hypertension patients was higher than mild hypertension patients (P ＜ 0.05 ), and the serum Hcy level of severe hypertension patients was higher than moderate hypertension patients( P ＜0.05). The serum Hcy level of hypertension group, cerebral infarction group, hypertension and cerebral infarction group was higher than the control group(all P ＜0.01 ),and the serum Hcy level of hypertension and cerebral infarction group was higher than hypertension group,cerebral infarction group( P ＜ 0.05). The incidence of large area infarction, recurrent infarction,multifocal infarction of hypertension and cerebral infarction group were higher than cerebral infarction group( all P ＜ 0.05). Conclusion The increase of serum Hcy level had a certain relationship with hypertension complicated with cerebral infarction, and it was related to the severity of cerebral infarction. Conventional Hcy level detection of patients had important clinical value for prediction,treatment and prognosis of patients with primary hypertension and acute cerebral infarction. Key words: Primary hypertension;  Acute cerebral infarction;  Homocysteine