2008•肿瘤研究与临床Requires access
Expression and significance of CD44v6 in non-small-cell lung cancer
Qiquan Yu, De-yi Shen, Weizhen Shou, Qi Bao
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Abstract
Objective To study the expression of CD44v6 in non-small-celt lung cancer and significance in judgement of prognosis.Methods CD44v6 expression in non-small-cell lung cancer tissues was detected in 62 patients with lung cancer operation in 1995-2002 year by immunohistohemistry method.Results The positive rate of CD44v6 in NSCLC was 61.3%,which was related to lymph node metastasis and 3-year survival rate in patients,but not to cell differentiation,pathological sort and TNM stage.Conclusion The positive expression of CD44v6 may be involved in lymph node metastasis and survival rate in NSCLC patients.It might be useful to evaluate the possibility of cancer metastasis and prognosis.
Key words:
Carcinoma,non-small-cell lung; CD44v6; Immunohistochemistry