A comparison of parecoxib sodium and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy

Objective To investigate the postoperative analgesia effect of parecoxib sodium and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy.Methods Sixty children,aged 5 y-8 y,scheduled for endoscopic adenoidectomy and tonsillectomy under general anesthesia were randomly divided into group A(parecoxib sodium),group B(flurbiprofen axetil),group C (normal saline)(n=20).Parecoxib sodium 1 mg/kg and flurbiprofen axetil 1 mg/kg were administered intravenously 15 min before the start of operation,meanwhile children in group C received normal saline.The extubation time,agitation occurrences,recovery period pain scores,remifentanil dose and side effects were observed and compared.Results There was no difference between the three groups in operation time,extubation time and remifentanil dose (P＞0.05).The emergence of postoperative agitation was 5％ in group A and group B,55％ in group C,which was significantly lower in group A and group B than that in group C(P＜0.01).The pain scores of group C were significantly higher than those in group A and group B(P＜0.01).The emergence of nausea and vomiting was 5％ in group C.Conclusions Applying of parecoxib sodium and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy can provide a good analgesia effect,reduce postoperative agitation,and do not postpone the extubation time. Key words: Parecoxib sodium;  Flurbiprofen axetil ;  Analgesia;  Children;  Tonsillectomy;  Adenoidectomy