Clinical observation of flurbiprofen axetil injection preemptive analgesia in children undergoing tonsillectomy

Objective To investigate the safety and efficacy of flurbiprofen axetil injection preemptive analgesia in children undergoing tonsillectomy. Methods Sixty children aged from 3 to 12 year undergoing tonsillectomy were randomly divided into three groups. Patients in group A received flurbiprofen axetil injection at 1 mg/kg disage before anesthesia induction(diluted the drug to 5 mL with normal saline).Patients in group B received the same dosage after removal tracheal catheter. Patients in group C received 5 mL normal saline as control. Pain scores, coagulation disfunction, nausea and vomiting were observed at 1,2,4,8,12,24 h after operation. Results Pain scores in group C at all time points were significantly higher than those in group A and in group B(P 0.05). Pain scores in group B at all time points were significantly higher than those in group A(P 0.05). There were no difference in the incidence of respiratory depression, coagulation disfunction, postoperative nausea and vomiting among three groups(P 0.05). Conclusion Flurbiprofen axetil injection could offer preemptive analgesia in children undergoing tonsillectomy with effectively and safely.