Clinical analysis of pulmonary surfactant in treatment of 30 cases with neonatal respiratory distress syndrome

Objective To explore the effect of pulmonary surfactant(PS) in the treatment of neonatal respiratory distress syndrome(NRDS).Methods According to whether using the PS,60 NRDS patients were divided into treatment group and control group.The blood-gas analysis index,oxygen time,mechanical ventilation time,hospitalization time and other indicators were analyzed.Results After 6h treatment,blood pH value (7.41 ± 0.11),PaO2 (69.8 ± 11.9) mm Hg and PaCO2 (48.7 ± 11.1)mm Hg in the treatment group were higher than those of the control group (7.24 ±0.13),(53.3 ±9.8)mm Hg,(59.1 ± 12.7)mm Hg(t =3.35,2.88,3.24,all P ＜0.05).In the treatment group,oxygen time (98.2 ± 29.2) h,the time of mechanical ventilation (77.6 ± 30.4) h and hospitalization time (12.9 ± 1.7)d,were also shorter than those of the control group (143.9 ± 26.5) h,(121.4 ± 22.9) h,(17.6 ±2.1) d (t =4.56,5.32,4.86,all P ＜ 0.05).Conclusion The application of PS in the treatment of NRDS can improve the lung function and lung aeration and reduce the time of mechanical ventilation. Key words: Pulmonary surfactants ;  Respiratory distress syndrome;  Infant, neonate