Neonatal respiratory distress syndrome of early lung surfactant therapy clinical observation

Objective To evaluate the pulmonary surfactant for neonatal respiratory distress syndrome(NRDS) treatment.Methods: 100 patients were randomly divided into treatment NRDS group of 50 patients and a control group of 50 patients,two groups were given conventional treatment such as mechanical ventilation,on the basis of the treatment group given intratracheal instillation of pulmonary surfactant,a dose of 100 mg / kg.Results: the treatment group survival rate higher than that of control group,(χ2 = 3.679,P 0.05);the treatment group ventilation time were significantly lower than the control group(χ2 = 5.88,P 0.05);the treatment group after treatment with 6,12,24,48h,PaO2,OI,a/A PO2,blood gas analysis and the control group comparison,(all P 0.05 or 0.01);treatment group after treatment in each period of mechanical ventilation parameters FiO2,VEI,MAP and control group comparison,(all P 0.05 or 0.01).Conclusion: Pulmonary surfactant on NRDS satisfactory outcome,it is worth promoting.