Effect of Atorvastatin on endothelial function in hypertensive patients

Objective To investigate the influence and significance of atorvastatin on endothelium dependent vasodilatation function in hypertensive patients without hyperlipemia.Methods One hundred and sixteen hypetensives without hyperlipemia were randomly divided into atorvastatin group (n =58) and control group(n =58).Patients in control group were treated by routine treatment,and patients in atorvastatin group were treated with atorvastatin 10 mg/d on the basis of the routine treatment,the course of treatment were 8 weeks.Nitric oxide(NO) and vascular false hemophilia factor (vWF) levels were measured before and after 8 weeks treatment.Results Before treatment,the plasma levels of NO and vWF had no statistically significant difference between the two groups(P ＞0.05) ; But after 8 weeks treatment,there were statistically significant differences of plasma levels of NO and vWF between the two groups (P ＜ 0.05).Conclusions Atorvastatin improves endothelial function in hypertensives without hyperlipemia,it has clinical application value. Key words: Lipid ;  Hypertension ;  Atorvastatin ;  Nitric oxide ;  Vascular false hemophilia factor