2010•International Journal of Dermatology and VenereologyRequires access

Efficacy of CO2 laser in combination with 5-aminolevulinic acid-photodynamic therapy for condyloma acuminaum

Zhi‐Ming Yu, Limin Cai, Shuyun Zheng, Xiuying Zhang

Abstract

Objective To evaluate the effect of CO2 laser in combination with 5-aminolevulinic acidphotodynamic therapy (ALA-PDT) on clearance and recurrence of condyloma acuminatum (CA). Methods A total of 124 patients with CA were randomly and equally divided into two groups to be treated with CO2 laser plus ALA-PDT (test group) or CO2 laser only (control group). Results The cure rate and recurrence rate were 90.6% (58/62) and 9.4% (4/62), respectively in the test group, 76.7% (46/62) and 23.3% (16/62)respectively in the control group. There was a statistical difference in the cure rate and recurrence rate between he two groups (both P ＜ 0.05). Conclusion CO2 laser in combination with ALA-PDT is superior to CO2 laser alone in the treatment of CA. Key words: Condylomata acuminata; Aminolevulinic acid; Photochemotherapy; Lasers

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Key concepts: Photodynamic therapy, Condyloma Acuminatum, Cure rate, Medicine, Laser, Significant difference, Dermatology, Urology