CO2 LASER PLUS PHOTODYNAMIC THERAPY VERSUS CO2 LASER IN THE TREATMENT OF CONDYLOMA ACUMINATUM: A RANDOMIZED COMPARATIVE STUDY

To compare the efficacy and safety of CO2 laser plus 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) with CO2 laser for the treatment of multiple condyloma acuminatum (CA), 120 patients with multiple CA were allocated into two groups — combined group ( CO2 laser plus ALA-PDT, n = 60) and CO2 laser group ( CO2 laser plus placebo-PDT, n = 60). After CO2 laser, a 20% ALA or a placebo solution was applied to the CA area 3 h before illumination with red light (635 nm, 100 mW/cm2, 80 J/cm2). The treatment was repeated seven days after the first treatment if the lesions were not completely resolved. The complete response rate, recurrence rate and adverse effects in the two groups were analyzed. After two treatments, the complete response rates in the CO2 laser group and combined group were 100% (509/509) and 100% (507/507) in the CA (p > 0.05), respectively. The recurrence rates in the CO2 laser group and combined group were 44.9% (229/509) and 10.6% (54/507) in the CA (p < 0.05), respectively. The adverse effects in CO2 laser group was more than that in combined group. The combined group is a more effective treatment for multiple CA compared with CO2 laser group. T/S. Style the highlighted text as abstract.