Expression and clinical significance of P53 and Ki-67 in lung cancer

Objective To investigate the expression and clinical significance of P53 and Ki-67 in lung cancer tissues.Methods The expressions of P53 and Ki-67 in 233 specimens of lung cancer were detected by SP immunohistochemistry,and were analyzed with clinical data.Results The positive expression rates of P53 and Ki-67 in lung cancer tissue were 80.7％ and 99.6％ respectively.In those specimens with positive expression of P53 and Ki-67,44.2％ and 57.2％ were low level expression respectively.There was no statistical correlation between the P53 expression and histologic type of lung cancer.Unlikely,the positive expression of Ki-67 was high in squamous carcinoma,and was low in adenocarcinoma and abronchioalveolar carcinoma. The expression rate of P53 in lung cancer with metastasis of lymphonodus was 95.0％,higher than that without metastasis.But the expression rate of Ki-67 had no relationship with metastasis of lymphonodus.Conclusions The positive expression rates of P53 and Ki-67 in lung cancer tissue are high,but nearly half are at low level.P53 and Ki-67 may involve in the occurrence and development of lung cancer. The expression rate of P53 is more relevant to metastasis of lymphonodus than that of Ki-67,while Ki-67 expression level is more relevant to histologic type of lung cancer. Key words: Lung cancer;  P53;  Ki-67;  Immunohistochemistry