Expression of Ki67 Gene in Primary Lung Cancer:Relation with the Clinicopathological Parameters and Prognosis of Patients

Objective To investigate the relationship of Ki67 with the clinicopathological parameters and prognosis of primary lung cancer patient. Methods The expression of Ki67 gene were detected in 166 lung cancer samples and 37 benign lesion tissues of lung as control by immunohistochemistry. Results (1) The Ki67 index was significantly higher in lung cancer tissues than in benign lesion tissues(P0.01), otherwise, no notable difference was found between normal tissues adjacent to cancer and controls(P0.05); (2) The expression level of Ki67 gene was closely related to histological classification and cancer cell differentiation(P0.05), and there was no significant relationship between Ki67 expression and PTNM stages, lymph node involvement, smoking habit, sexuality and age of lung cancer patients (P0.05); (3) The postoperative survival time of patients in high Ki67 expression group was significantly shorter than those in low expression group (P0.01), and this reverse association between Ki67 index and survival time is independent to PTNM stages of patients(P0.05). Conclusion Ki67 is a favorable marker to proliferation of lung cancer cells, and can provide useful information for diagnosis and prognosis of lung cancer patients.