2018•Chin J Postgrad MedRequires access
Comparative study on the effects of urapidil and sodium nitroprusside on blood pressure in patients with hypertensive intracerebral hemorrhage
Dongyuan Liu, Hao Wang, Hongbing Zhang, Ziming Hou
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Abstract
Objective
To compare the effects of urapidil and sodium nitroprusside on blood pressure and prognosis in patients with hypertensive intracerebral hemorrhage.
Methods
One hundred and fifty patients with hypertensive intracerebral hemorrhage from January to December 2017 were divided into urapidil group and sodium nitroprusside group according to the medication, each group with 75 patients. The changes of blood pressure, heart rate, hematoma size and neurological function were compared between the two groups.
Results
At 10 and 30 min after treatment, the systolic blood pressure and diastolic blood pressure of patients in urapidil group were lower than those in sodium nitroprusside group (P 0.05). At 10, 30, 60, 120 and 240 min after treatment, the heart rate of patients in urapidil group were significantly lower than those in sodium nitroprusside group (P 0.05). At 1 month after treatment, the neurological scores between the two groups were significantly different: (10.1 ± 2.1) scores vs. (13.8 ± 5.9) scores, P<0.05.
Conclusions
Urapidil can effectively control blood pressure in patients with hypertensive intracerebral hemorrhage. Moreover, it exerts better long-term neuroprotective effect, compared with sodium nitroprusside.
Key words:
Intracerebral hemorrhage, hypertensive; Urapidil; Sodium nitroprusside