Therapeutic effect and safety of urapidil for treatment of hypertensive urgency

Objective:To observe antihypertensive effect and safety of urapidil and sodium nitroprusside in treatment of hypertensive urgency.Methods: A total of 86 patients with hypertensive urgency were randomly divided into urapidil group(n=43,received urapidil through venous pump) and sodium nitroprusside group(n=43,received sodium nitroprusside through venous pump as control).Blood pressure and therapeutic effects were monitored and observed in the two groups,and safety of reaching initial goal of treatment of hypertensive urgency was also investigated.Results: Before therapy the blood pressures of urapidil group and sodium nitroprusside group were no significant difference[(219.21±27.92)/(148.79±14.15)mmHg vs.(226.98±23.00)/(148.03±11.49)mmHg,P0.05];after administer 5 min,blood pressures significantly decreased in the two groups,and blood pressure of each time segment was significantly lower than before treatment(P0.01),after administer 360 min the blood pressures of urapidil group and sodium nitroprusside group respectively decreased to [(143.53±11.16)/(89.56±8.01)mmHg]、[(143.88±8.09)mmHg /(90.16±6.44)mmHg];there was no significant difference in therapeutic effect between the two drugs(P0.05),both of them can reach initial goal of treatment.Before therapy the heart rate(HR)of urapidil group and sodium nitroprusside group were no significant difference[(98.28±11.52)times/min vs.(98.09±9.23)times/min],after administer 360 min HR of urapidil group decreased to(96.95±11.37)times/min,but HR of sodium nitroprusside group increased to(100.33±10.96)times/min,urapidil group was better than sodium nitroprusside group in lowering heart rate(P0.05).Conclusion:Urapidil has remarkable therapeutic effect on hypertensive urgency,and possesses high safety,should be promoted in clinic.