Efficacy of vaginal misoprostol with mifepristone and misoprostol alone in the termination of pregnancy during second trimester

Background: Abortions in second trimester is a major obstetric challenge and is considered to be less safe than first trimester abortions. Vaginal misoprostol with Mifepristone is an efficient modality in the second trimester abortions. This study was designed to assess the efficacy of misoprostol with mifepristone and misoprostol alone in the termination of pregnancy during second trimester. Materials and methods: A total of 120 cases requesting abortion in their second trimester with gestation age 14-20 weeks were recruited. The study participants were randomly divided into two groups. Group 1 administered with vaginal misoprostol with mifepristone and group 2 administered with vaginal misoprostol alone. Results: The mean interval between induction and abortion in group 1 was 8.74 hours and in group 2 was 11.98 hours. In group 1, complete abortion was seen in group 2, 65% showed complete abortion. Post- operative symptom like nausea, postoperative pain and vomiting were more common in group 2 than group 1. 100% cases where as in % success rate was seen in vaginal misoprostol with mifepristone group. Conclusion: Mifepristone with misoprostol is showing dominant outcome than misoprostol alone in related to induction abortion interval, success rate and in the complete abortion rate.