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Determination and significance of SAA and hs-CRP in patients with AS.

Yuehua Li, Ji Q, Shuying Li

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Abstract

Objective To explore the function of serum amyloid-A(SAA)in formation of atherosclerosis(AS).Methods Thirty-two patients with both MS and CHD(CHD+MS group),22 patients with MS(MS group)simply were enrolled in this study,and 28 heathy subjects were choosed as the control group.SAA level in the three groups were measured by enzyme linked immunosorbent assay,while the hs-CRP level were measured by super-sensitivity immunoturbidimetry,and IMT were detected by B-mode ultrasonography.Results IMT,SAA and hs-CRP level in CHD+MS group and MS group were higher than those in the control group.IMT,SAA and hs-CRP level in CHD+MS group were higher than those in MS group.Level of SAA was positively correlated with hs-CRP and IMT.Level of hs-CRP was positively correlated with IMT.Conclusions SAA and hs-CRP are not only inflammatory maker of AS,but also participates the pathogenesis of AS possibly.

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What this paper is about

Objective To explore the function of serum amyloid-A(SAA)in formation of atherosclerosis(AS).Methods Thirty-two patients with both MS and CHD(CHD+MS group),22 patients with MS(MS group)simply were enrolled in this study,and 28 heathy subjects were choosed as the control group.SAA level in the three groups were measured by enzyme linked immunosorbent assay,while the hs-CRP level were measured by super-sensitivity immunoturbidimetry,and IMT were detected by B-mode ultrasonography.Results IMT,SAA and hs-CRP level in CHD+MS group and MS group were higher than those in the control group.IMT,SAA and hs-CRP level in CHD+MS group were higher than those in MS group.Level of SAA was positively correlated with hs-CRP and IMT.Level of hs-CRP was positively correlated with IMT.Conclusions SAA and hs-CRP are not only inflammatory maker of AS,but also participates the pathogenesis of AS possibly.

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Available abstract

Objective To explore the function of serum amyloid-A(SAA)in formation of atherosclerosis(AS).Methods Thirty-two patients with both MS and CHD(CHD+MS group),22 patients with MS(MS group)simply were enrolled in this study,and 28 heathy subjects were choosed as the control group.SAA level in the three groups were measured by enzyme linked immunosorbent assay,while the hs-CRP level were measured by super-sensitivity immunoturbidimetry,and IMT were detected by B-mode ultrasonography.Results IMT,SAA and hs-CRP level in CHD+MS group and MS group were higher than those in the control group.IMT,SAA and hs-CRP level in CHD+MS group were higher than those in MS group.Level of SAA was positively correlated with hs-CRP and IMT.Level of hs-CRP was positively correlated with IMT.Conclusions SAA and hs-CRP are not only inflammatory maker of AS,but also participates the pathogenesis of AS possibly.

Key concepts: Serum amyloid A, Internal medicine, Pathogenesis, Medicine, C-reactive protein, Gastroenterology, Immunology, Endocrinology

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Determination and significance of SAA and hs-CRP in patients with AS. — Research Paper | ScholarLens