Relationship between serum amyloid A and coronary heart disease

Objective:To study the relationship between plasma levels of serum amyloid A protein(SAA) concentrations and clinical course(including prognosis) in patients with CHD.Method:88 patients with CHD and 92 controls were enrolled.The clinical data were obtained,and the plasma concentration of hsCRP and SAA were measured.Result:The concentration of SAA is highly correlated with hs-CRP(r=0.807,P0.01).We demonstrated that the concentration of SAA and hs-CRP were significantly higher in group of ACS than in group of SAP and control subjects(P0.01).There is significant difference between the Gensini score of 20-40(or40) and Gensini score 20,but there is no relationship with lesions area.We demonstrated that the incidence of CHD is higher with the concentration of SAA≥4.80 mg/L or hs-CRP ≥3.73 mg/L than lower,and the sensitivity are 80.7%(SAA) and 61.4%(hsCRP).There is significant difference in prognisis of revascularization between two SAA groups(P0.05).The relative importance comparison study among risk factors of CHD: SAATCthe history of hypertensionsmokingage.Conclusion:Inflammation is associated with coronary artery disease progression.SAA may have a potential role in predicting the severity of CHD with high sensitivity.SAA may predict the prognosis of CHD in many aspecters.