Value of the detection of 21 subtypes of HPV in the diagnosis and prediction of cervical lesions.

Objective To investigate the relation between different subtypes of HPV and cervical lesions.Methods Three hundreds and sixty patients with cervical lesions were diagnosed by pathological examination 254 cases of cervicitis/ cervical condyloma acuminate,52 cases of cervical intraepithelial neoplasia(CIN,12 cases of CINⅠ,16 cases of CINⅠ,24 cases of CINⅢ),52 cases of cervical cancer,the HPV subtypes were detected by flow-through hybridization gene chip technology,the HPV infection of different lesions were analyzed.Results The HPV infection rate of this group was 83.3%(300/360);The rates of high-risk HPV infection were significantly higher than that of low-risk HPV infection in cervicitis /cervical condyloma acuminate,CIN and cervical cancer(P0.01);The rates of high-risk HPV infection increased with the degree of cervical lesions;The rates of single HPV subtype infection were significantly higher than that of multiple HPV subtypes infection in different cervical lesions(P0.01),the rates of multiple HPV subtypes infection increased with the degree of cervical lesions.The pathogenicity of different HPV subtypes was different.Conclusion The detection of HPV subtypes can be used in the screening of cervical lesions and predicting of progression.