Human papilloma virusinfection in patients with cervical lesions and distribution of its subtypes

OBJECTIVE To investigate human papilloma virus(HPV) infections and the distribution of its subtypes in patients with cervical lesions and put forward counter measures for prevention and treatment of the disease.METHODS Cervical exfoliated cells collected from a total of 600 patients with cervical lesions were detected with Flow-through hybridization and gene chip technology,and followed by a complete evaluation of the HPV infection in related to different subtypes of cervical lesions.RESULTS The total HPV infection rate reached 78.0%.The high-risk and low-risk HPV infection rates of patients with cervicitis/ condyloma acuminatum were 73.1% and 18.1%,respectively.The difference was statistically significant(P0.05).The high-risk and low-risk HPV infection rates of patients with cervical intraepithelial neoplasia(CIN) were 82.6% and 7.9%,respectively,the difference was statistically significant(P0.01).The high-risk and low-risk HPV infection rates of patients with cervical cancer were 96.0% and 0,respectively,the difference was statistically significant(P0.01).The high-risk HPV infection rate increased with the degree of exacerbating of cervical lesions.The rate of single-type HPV infection was significantly higher than that of multi-type HPV infection in all kinds of cervical lesions(P0.01),while the rate of multi-type HPV infection increased with the increasing severity of cervical lesions.Different subtypes of HPV distributed differently in cervix lesions.CONCLUSION Detection of HPV subtypes is helpful for screening of the cervical lesions and diagnosis of the condition.For those patients infected especially with high-risk HPV,it is critical to conduct the early diagnosis,timely treatment and close follow-up to block the persistent HPV infection and prevent cervical cancer.