2002•Chinese HepatologyRequires access

Effects of lamivudine in the hepatic fibrosis patients with chronic hepatitis B:(I) the influence on the fibrosis serum markers

XU Saifang

Abstract

Objective To observe the changes of fibrosis serum markers of the patients with chronic hepatitis B with lamivudine treatment. Methods Serum hyaluronic(HA)、laminin(LN)、type Ⅲ procollagen(PⅢP) and type Ⅳ collagen (ⅣC) were measured in forty patients by radioimmunoassay at 0, 3, 6, 9 and 12 months. Result Serum levels of HA、LN、 PⅢP and ⅣC were gradually decreased till the 12 month with treatment, especially HA. The correlation between serum HA and serum ALT and AST was good. The rates of efficacy were 25%(10/40) at 6 month and 70%(28/40, P 0.01 ) at 12 mouth. Conclusion Lamivudine showed a beneficial effect on hepatic fibrosis patients with chronic hepatitis B.

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Key concepts: Lamivudine, Gastroenterology, Medicine, Fibrosis, Internal medicine, Hyaluronic acid, Hepatic fibrosis, Chronic hepatitis