Effect of lamivudine combined with interferon on index of hepatic fibrosis in chronic hepatitis B

Objective To observe the effect of lamivudine combined with interferon on index of hepatic fibrosis in chronic hepatitis B.Methods 60 cases patients with chronic hepatitis B were randomly divided into treatment group and control group,each of 30 cases.Treatment group were treated with interferon alpha α-2b 5 million U intramuscular injection and lamivudine 0.1g oral;Control group only received lamivudine,usage,course of treatment with the treatment group.Observed the index of hepatic fibrosis,liver function and serum virological marker before and after treatment of two groups.Results After treatment,hyaluronic acid(HA),laminin(LN) and Ⅲ procollagen peptide(PⅢP),collagen type IV(C-Ⅳ),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) of two groups were significantly decreased,the difference were statistically significant(P0.05 or P0.01);After treatment,the level of HA and C-Ⅳ were lower than those of control group,the difference was statistically significant(P0.05).HBV-DNA negative rate of treatment group was higher than that of control group,the difference was statistically significant(P0.05).Conclusion lamivudine combined with interferon can restrain replication of HBV in patient with chronic hepatitis B,improve the index of hepatic fibrosis,while relieve degree of hepatic fibrosis obviously.