Observations on the influence of recombinant IFN-γon the fibrosis serum markers of chronic hepatitis B

Objective To observe the changes of fibrosis serum markers and safety of recombinant IFN γ in treatment of patients with fibrosis of hepatitis B. Methods Forty patients with chronic hepatitis B were randomly divided into group A and B. Patients in both groups received conventional drugs for 9 months, however, patients in group A also received IFN γ concomitently for 9 months. Serum HA, LN, PⅢNP and Col Ⅳ were measured in the above patients by radioimmunoassay at 0,3,6,9 months and three months after cessation of treatment.Results The serum levels of HA、LN、PⅢNP and Col Ⅳ were gradually decreased till nadir at 9 month after treatment in group A, but there were no change during the period in group B. The rates of efficacy were 61.1%(11/18, 2 cases were lost to follow up) in group A and 10.0% in group B, there was significant difference between the two groups ( P =0.004).Conclusion IFN γ combined with conventional drugs is effective in treatment of fibrosis of chronic hepatitis B.