2006•Linchuang gandanbing zazhiRequires access

Influence on serum hepatic fibrosis index in lamivudine-treated patients with chronic hepatitis B

Beijing Luo

Abstract

Objective To investigate the changes of serum fibrosis markers of lamivudine-treated patients with chronic hepatitis B.Methods 81 patients with chronic hepatitis B were randomly divided into treatment group and control group.The treatment group(42 patients) were treated with lamivudine,while the control group(39 patients) were treated with liver-protecting drugs.The levels of serum byaluronic acid(HA),laminin(LN),type Ⅲ procollagen(PCⅢ) and type Ⅳ collagen(ⅣC) of each group were detected before and after treatment.Results The level of serum HA,LN,PCⅢ and ⅣC significantly decreased after the treatment of lamivudine(P0.01) and the level of serum HA,LN,PCⅢ and ⅣC of treatment group was obviously different from that of comtrol group after the treatment of lamivudine(P0.01).Conclusion Lamivudine could obviously decrease the serum hepatic fibrosis index in patients with chronic hepatitis B.

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Key concepts: Lamivudine, Medicine, Gastroenterology, Internal medicine, Chronic hepatitis, Hepatic fibrosis, Fibrosis, Procollagen peptidase