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2015•China Foreign Medical TreatmentRequires access

Expression and Significance of DLC-1 and CyclinD1 in Cervical Squamous Cell Carcinoma

Xiaoya Chen

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Abstract

Objective To investigate the expression of DLC-1 and cyclin D1 in cervical squamous cell carcinoma. Methods 62 cases of cervical squamous cell carcinoma samples, 38 cases of cervical intraepithelial neoplasia samples, 26 cases of normal cervical tissue samples from January 2005 to December 2013 were selected, and the expression of DLC-1 and cyclin D1 were detected by immunohistochemistry SP method. Results The positive expression of DLC-1 in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue, were 27.4%, 76.3%, and 92.3% respectively, the difference was statistically significant(P0.05); The positive expression of DLC-1 in high, middle, and low pathological grade were 42.9% 、27.9%、16.7% respectively, the difference was statistically significant(P0.05); The positive expression of DLC-1 in Ⅰ~Ⅱa was 41.4%, which was significantly higher thanⅡb~Ⅳ15.2%(P0.05); The positive expression of DLC-1 in patients without lymph node metastasis was34.9%, which was significantly higher than patients with lymph node metastasis 10.5%(P 0.05)。 The positive expression of cyclin D1 in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue, were 66.1%, 5.3%, 0%respectively, the difference was statistically significant(P 0.05); The positive expression of cyclin D1 in high, middle, and low pathological grade were 42.9%, 67.4%, 75.0% respectively, the difference was statistically significant(P0.05); The positive expression of cyclin D1 in Ⅰ~Ⅱa was 48.3%, which was significantly higher thanⅡb~Ⅳ81.8%(P0.05); The positive expression of cyclin D1 in patients without lymph node metastasis was 58.1%, which was significantly higher than patients with lymph node metastasis 84.2%(P0.05).The expression of DLC-1 and cyclin D1 in cervical squamous cell carcinoma showed a negative correlation(r=-0.519, P0.05). Conclusion The expression of DLC-1 in squamous cell carcinoma is lower, and expression of cyclin D1 in squamous cell carcinoma is higher, and both of them are closely related to the stage, grade, and lymph node metastasis of squamous cell carcinoma.

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Objective To investigate the expression of DLC-1 and cyclin D1 in cervical squamous cell carcinoma. Methods 62 cases of cervical squamous cell carcinoma samples, 38 cases of cervical intraepithelial neoplasia samples, 26 cases of normal cervical tissue samples from January 2005 to December 2013 were selected, and the expression of DLC-1 and cyclin D1 were detected by immunohistochemistry SP method. Results The positive expression of DLC-1 in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue, were 27.4%, 76.3%, and 92.3% respectively, the difference was statistically significant(P0.05); The positive expression of DLC-1 in high, middle, and low pathological grade were 42.9% 、27.9%、16.7% respectively, the difference was statistically significant(P0.05); The positive expression of DLC-1 in Ⅰ~Ⅱa was 41.4%, which was significantly higher thanⅡb~Ⅳ15.2%(P0.05); The positive expression of DLC-1 in patients without lymph node metastasis was34.9%, which was significantly higher than patients with lymph node metastasis 10.5%(P 0.05)。 The positive expression of cyclin D1 in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue, were 66.1%, 5.3%, 0%respectively, the difference was statistically significant(P 0.05); The positive expression of cyclin D1 in high, middle, and low pathological grade were 42.9%, 67.4%, 75.0% respectively, the difference was statistically significant(P0.05); The positive expression of cyclin D1 in Ⅰ~Ⅱa was 48.3%, which was significantly higher thanⅡb~Ⅳ81.8%(P0.05); The positive expression of cyclin D1 in patients without lymph node metastasis was 58.1%, which was significantly higher than patients with lymph node metastasis 84.2%(P0.05).The expression of DLC-1 and cyclin D1 in cervical squamous cell carcinoma showed a negative correlation(r=-0.519, P0.05). Conclusion The expression of DLC-1 in squamous cell carcinoma is lower, and expression of cyclin D1 in squamous cell carcinoma is higher, and both of them are closely related to the stage, grade, and lymph node metastasis of squamous cell carcinoma.

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Available abstract

Objective To investigate the expression of DLC-1 and cyclin D1 in cervical squamous cell carcinoma. Methods 62 cases of cervical squamous cell carcinoma samples, 38 cases of cervical intraepithelial neoplasia samples, 26 cases of normal cervical tissue samples from January 2005 to December 2013 were selected, and the expression of DLC-1 and cyclin D1 were detected by immunohistochemistry SP method. Results The positive expression of DLC-1 in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue, were 27.4%, 76.3%, and 92.3% respectively, the difference was statistically significant(P0.05); The positive expression of DLC-1 in high, middle, and low pathological grade were 42.9% 、27.9%、16.7% respectively, the difference was statistically significant(P0.05); The positive expression of DLC-1 in Ⅰ~Ⅱa was 41.4%, which was significantly higher thanⅡb~Ⅳ15.2%(P0.05); The positive expression of DLC-1 in patients without lymph node metastasis was34.9%, which was significantly higher than patients with lymph node metastasis 10.5%(P 0.05)。 The positive expression of cyclin D1 in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue, were 66.1%, 5.3%, 0%respectively, the difference was statistically significant(P 0.05); The positive expression of cyclin D1 in high, middle, and low pathological grade were 42.9%, 67.4%, 75.0% respectively, the difference was statistically significant(P0.05); The positive expression of cyclin D1 in Ⅰ~Ⅱa was 48.3%, which was significantly higher thanⅡb~Ⅳ81.8%(P0.05); The positive expression of cyclin D1 in patients without lymph node metastasis was 58.1%, which was significantly higher than patients with lymph node metastasis 84.2%(P0.05).The expression of DLC-1 and cyclin D1 in cervical squamous cell carcinoma showed a negative correlation(r=-0.519, P0.05). Conclusion The expression of DLC-1 in squamous cell carcinoma is lower, and expression of cyclin D1 in squamous cell carcinoma is higher, and both of them are closely related to the stage, grade, and lymph node metastasis of squamous cell carcinoma.

Key concepts: Medicine, Cervical intraepithelial neoplasia, Immunohistochemistry, Cyclin D1, Pathological, Significant difference, Pathology, Basal cell

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Expression and Significance of DLC-1 and CyclinD1 in Cervical Squamous Cell Carcinoma — Research Paper | ScholarLens