2013•Journal of Taishan Medical CollegeRequires access
The expression and correlation of Cyclin D1 and P27 in cervical squamous cell carcinoma tissue
Yin Wang
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Abstract
Objective:To investigate the expression and its correlation of Cyclin D1 and P27 in cervical squamous cell carcinoma.Methods:The expression of Cyclin D1 and P27 was investigated using immunohistochemical staining in 70 cases of normal cervical epithelia and 102 cases of cervical squamous cell carcinoma.The levels of Cyclin D1 and P27 expression in cervical squamous cell carcinoma were ana1yzed against clinical pathological factors and its correlation.Results:The positive rate of Cyclin D1 on the cervical squamous cell carcinoma tissue was higher than that on the normal cervical tissue,with significant difference(χ2= 50.12,P 0.05);the positive rate of P27 on the cervical squamous cell carcinoma tissue was lower than that on the normal cervical tissue,with significantly difference(χ2= 71.70,P 0.05).The positive rate of Cyclin D1 in cervical squamous cell carcinoma in late clinical stage,low differentiation and lymph node metastasis in patients with positive expression rate were significantly higher than those of early clinical stage,lymph node metastasis in patients with no high differentiation,and the differences were statistically significant( P 0.05);the positive rate of P27 in cervical squamous cell carcinoma in late clinical stage,low differentiation and lymph node metastasis in patients with positive expression rate were significantly lower than those of early clinical stage,lymph node metastasis in patients with no high differentiation,and the difference was statistically significant( P 0.05).Conclusion:The expression of Cyclin D1 and P27 in cervical squamous cell carcinoma is negatively correlated,which indicates that Cyclin D1 and P27 play a role of the synergistic affection in the promotion and development of cervical squamous cell carcinoma.