Distribution and drug resistance of pathogens causing respiratory tract infections in children of pediatric department

OBJECTIVE To explore the distribution and drug resistance of the pathogens causing respiratory tract infections in the children of pediatric department so as to provide guidance for reasonable clinical use of antibiotics.METHODS The clinical data of 120 children with respiratory tract infections who were hospitalized the pediatric department from Jan 2010 to Dec 2013 were retrospectively analyzed,then the bacterial identification was performed by using VITEK-32 automatic microorganism analyzer of BioMerieux,France;the drug susceptibility testing was carried out with the use of K-B method,and the drug resistance was analyzed.RESULTS Totally 287 strains of pathogens have been isolated from 352 submitted sputum specimens that were obtained from the 120 children with respiratory tract infections,including 171(59.58%)strains of gram-negative bacilli,75(26.13%)strains of gram-positive cocci,and 41(14.29%)strains of fungi;the Klebsiella pneumoniae(68strains),Escherichia coli(38strains),Pseudomonas aeruginosa(29strains),and Acinetobacter baumannii(15strains)were the predominant species of gram-negative bacilli,accounting for 23.69%,13.24%,10.10%,and 5.23%,respectively;the Staphylococcus aureus(40strains),Staphylococcus epidermidis(22strains),and Streptococcus pneumoniae(9strains)were dominant among the gram-positive cocci,accounting for 13.94%,7.67%,and3.13%,respectively.The gram-negative bacilli were highly resistant to penicillin,piperacillin,ampicillin,and tetracycline,with the drug resistance rates more than 72.00%,while the strains were highly susceptible to piperacillin-tazobactam,cefoperazone-sulbactam,imipenem,meropenem,and amikacin.The gram-positive cocci were highly resistant to penicillin,azithromycin,tetracycline,and ciprofloxacin,with the drug resistance rates more than 88.00%, while the strains were highly susceptible to vancomycin,levofloxacin,and rifampicin.CONCLUSIONIt is an effective way to reasonably use antibiotics based on the results of drug susceptibility testing so as to reduce the incidence of respiratory tract infections in the pediatric department.