Distribution and drug resistance of pathogens causing hospital-acquired pneumonia in ICU

OBJECTIVE To investigate the distribution and drug resistance of the pathogens causing hospital-acquired pneumonia(HAP) in ICU so as to provide basis for the clinical reasonable use of antibiotics.METHODS The pathogens,which were isolated from the sputum specimens obtained from the HAP patients from Jan 2010 to Dec 2011,were retrospectively analyzed,the drug resistance was analyzed as well.RESULTS A total of 302 strains of pathogenic bacteria were isolated,including 211(69.9%) strains of gram-negative bacilli,66(21.8%) strains of fungi,and 25(8.3%) strains of gram-positive cocci.The top 5 pathogens isolated were Klebsiella pneumoniae(54 strains,17.9%),Pseudomonas aeruginosa(49 strains,16.2%),Escherichia coli(42 strains,13.9%),Candida albicans(38 strains,12.6%),Acinetobacter baumannii(25 strains,8.3%);the gram-negative bacilli were highly sensitive to imipenem,amikacin,cefoperazone/sulbactam,and piperacillin/tazobactam,C.albicans maintained high resistanle against clinical common antibiotics,no strains of vancomycin-resistant gram-positive cocci were detected.CONCLUSION The gram-negative bacilli are the main pathogens causing HAP in ICU,most of which are multidrug-resistant strains,it is necessary to strengthen the monitoring of drug resistance.