Research on distribution and drug resistance of pathogens in respiratory ward

OBJECTIVE To analyze the distribution and drug resistance of the pathogens causing lower respiratory tract infections in the respiratory ward in 2011 so as to provide basis for scientific use of antibiotics.METHODS The pathogens were isolated from clinical sputum specimens of the hospitalized patients who were diagnosed as lower respiratory tract infections,the surveillance of drug resistance was performed by using automatic bacterial identification system and drug susceptibility testing system.RESULTS The survey included 2822 patients with lower respiratory tract infections in the hospital.There were 326(74.8%) strains of gram-negative bacilli and 110(25.2%) strains of gram-positive cocci detected.The species of bacteria whose detection rates ranked top five were Klebsiella pneumoniae,Escherichia coli,Pseudomonas aeruginosa,Acinetobacter baumanii,and Staphylococcus aureus.The detection rates of ESBLs-producing K.pneumoniae and E.coli strains were 38.6% and 58.4%,respectively.The ESBLs-producing strains had a stronger resistance to most antibiotics than did the non-ESBLs-producing strains.The drug susceptibility rates of P.aeruginosa to amikacin,tobramycin,piperacillin,ciprofloxacin,and imipenem were above 70.0%.A.baumannii strains were highly drug resistant to commonly used antibioticsa,and no strains were found resistant to vancomycin or linezolid.CONCLUSION It is very important to observe the drug resistance of local pathogens and to master the characteristics of bacterial resistance and distribution so that a reasonable use of antimicrobials is guaranteed.